T Cell Exhaustion News

Latest Articles

• Metabolic Rewiring Emerges as Key Strategy to Help CAR-T Cells Survive and Destroy Solid Tumors

  Published: Apr 30, 2026

  Section: Health Technology

  Researchers are developing "metabolic reprogramming" techniques to help CAR-T cell therapies overcome the nutrient-deprived and toxic environments of solid tumors. By genetically a...

• University of Lausanne Researchers Identify Mitochondrial Metabolic Switch That Drives Immune Cell Exhaustion and Weakens Cancer Therapy

  Published: Mar 18, 2026

  Section: Research

  A study led by Professor Ping-Chih Ho has uncovered a molecular "bridge" that converts mitochondrial stress into the permanent genetic reprogramming of exhausted T cells. By identi...

• University of Pennsylvania Engineers Develop Universal Nanoparticle Therapy to Reinvigorate Exhausted T Cells in Solid Tumors

  Published: Mar 18, 2026

  Section: Science & Tech

  Researchers at the University of Pennsylvania have engineered a dual-function lipid nanoparticle (LNP) that simultaneously blocks immune-suppressing enzymes and delivers protein-co...