synthetic lethality News
Latest articles and news about synthetic lethality on AXL Media.
Latest Articles
- ALDH2 Enzyme Identified as Metabolic Achilles’ Heel for APC-Deficient Colorectal Cancer Cells
Published: Apr 21, 2026
Section: Medical News
A new study published in Genes & Diseases reveals that colorectal cancer cells lacking the APC tumor suppressor gene are selectively dependent on the enzyme ALDH2 for survival. Res...
- Repurposed Alcoholism Drug Disulfiram Exploits Genetic Vulnerability to Target APC-Deficient Colorectal Cancer Cells
Published: Apr 7, 2026
Section: Medical News
Researchers have identified a "synthetic lethal" strategy that uses the ALDH2 inhibitor disulfiram to kill colorectal cancer cells harboring mutations in the APC gene. The study, p...
- UCLA Research Identifies "Synthetic Lethality" Mechanism to Target Treatment-Resistant Small Cell Neuroendocrine Cancers
Published: Mar 24, 2026
Section: Health
Scientists at UCLA have discovered that aggressive neuroendocrine tumors lacking the RB gene become critically dependent on the E2F3 protein for survival. This genetic vulnerabilit...